Brent Wisse, MD
Brent E. Wisse

Brent E. Wisse, MD

email: [email protected]



Personal Data:

Place of Birth:               Pomona, CA

Citizenship:              USA



1991-1995              Medical School (MDCM) Class of 1995

              McGill University, Faculty of Medicine, Montreal, Quebec, Canada


1987-1991              Graduate Studies Research, Faculty of Science

              McGill University, Montreal, Quebec


1984-1987              B.Sc. Immunology

              McGill University, Faculty of Science, Montreal, Quebec


Postgraduate Training:

7/1999-6/2001              Fellow Metabolism, Endocrinology and Nutrition, University of Washington


7/1998-6/1999              Fellow Endocrinology and Metabolism, McGill University Hospital Centers, Montreal, Quebec, Canada

Chief Medical Resident, Royal Victoria Hospital, Montreal, Quebec (12/98-6/99)


7/1995-6/1998              Resident Internal Medicine, Royal Victoria Hospital, Montreal, Quebec


Faculty Positions Held:


2008-              Associate Professor, Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Harborview Medical Center, Seattle, Washington


2002-2008              Assistant Professor, Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Harborview Medical Center, Seattle, Washington


2001-2002              Acting Instructor, Division of Metabolism, Endocrinology and Nutrition. University of Washington


Hospital Positions Held:

2001-              Attending Physician, Harborview Medical Center and University of Washington Medical Center


2007-              Director HMC Glycemic Control Service



1987                                             B.Sc. with First Class Honors

1988-91                        McGill Major Fellowship, FCAR Fellowship, MRC Fellowship

1992-94                                  McConnell Award for Academic Achievement in Medicine (three times)

1992                                             Leukemia Research Award

1995                                             MDCM, Dean's Honor List, Cushing Prize

1997                                             Resident Research Award

1998                                             Resident Teaching Award

2000              Endocrine Fellows Foundation Grant


Medical Certificates:                                         

1998              ABIM, Board Certification in Internal Medicine                            

2001              ABIM, Board Certification in Endocrinology, Diabetes and Metabolism

2011              ABIM, Re-certification Endocrinology, Diabetes and Metabolism             



Washington State Medical License                            1999

US Medical License                                                        1997


Professional Organizations:

North American Association for the Study of Obesity              2000

Endocrine Society                                                                                    2001

Western Society of Clinical Investigation                                          2007


Teaching Responsibilities:

MCBD Block Director, teaching carbohydrate, protein and lipid metabolism

Energetics and Homeostasis Block - lecturer



First year Endo Fellows clinical research project: (last 5 years)

Jean-Jacques Nya-Ngatchou, Jane-Frances Chukwu, Marisela Noorhasan, Jeff Vercollone, Jennifer Rosenbaum

Clinical research projects:

Luisa Duran, MD (Fellowship Research Project 2012-2013)

Glycemic Control projects (Liz Berggren, Sean McCliment, Rachel Thompson, Scott Binns)

Basic science research projects:

Carlos Campos, PhD (NCI R21) – post-doc with R. Palmiter




Peer Reviewed Publications:


  1. You-Ten EK, Seemayer TA, Wisse B(E) and Lapp WS. Induction of a glucocorticoid sensitive F1 anti-parental mechanism that affects engraftment during graft-versus-host disease. J. Immunol. 1995 Jul; 155(1): 172-180
  2. Wisse BE, Campfield LA, Marliss EB, Morais JA, Tenenbaum R, Gougeon R. Effect of prolonged moderate and severe energy restriction and refeeding on plasma leptin concentrations in obese women. Am J Clin Nutr. 1999 Sep;70(3):321-30.
  3. Wisse BE, Frayo RS, Schwartz MW, Cummings DE. Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology. 2001 Aug;142(8):3292-301.
  4. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001 Aug;50(8):1714-9.
  5. Wisse BE, Schwartz MW. Role of melanocortins in control of obesity. Lancet. 2001 Sep 15;358(9285):857-9.
  6. Wisse BE, Schwartz MW. The skinny on neurotrophins. Nat Neurosci. 2003 Jul;6(7):655-6.
  7. Wisse BE, Schwartz MW, Cummings DE. Melanocortin signaling and anorexia in chronic disease states. Ann N Y Acad Sci. 2003 Jun;994:275-81.
  8. Wisse BE, Ogimoto K, Morton GJ, Wilkinson CW, Frayo RS, Cummings DE, Schwartz MW. Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis. Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1107-13. Epub 2004 Aug 10.
  9. Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol. 2004 Nov;15(11):2792-800.
  10. Wisse BE, Ogimoto K, Schwartz MW. Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins. Peptides. 2006 Feb;27(2):265-73.
  11. Ogimoto K, Harris MK Jr, Wisse BE. MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Endocrinology. 2006 Sep;147(9):4445-53. Epub 2006 Jun 15.
  12. Wisse BE, Ogimoto K, Morton GJ, Williams DL, Schwartz MW. Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance. Brain Res. 2007 May 4;1144:101-6. Epub 2007 Jan 27.
  13. Wisse BE, Ogimoto K, Tang J, Harris MK Jr, Raines EW, Schwartz MW. Evidence that LPS-induced anorexia depends upon central, rather than peripheral, inflammatory signals. Endocrinology. 2007 Nov;148(11):5230-7. Epub 2007 Aug 2.
  14. Klaff LS, Wisse BE. Current controversy related to glucocorticoid and insulin therapy in the intensive care unit. Endocr Pract. 2007 Sep-Oct;13(5):542-9.
  15. Wisse BE, Kim F, Schwartz MW. Physiology. An integrative view of obesity. Science. 2007 Nov 9;318(5852):928-9.
  16. Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW. Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1982-8. Epub 2008 Sep 4.
  17. Blevins JE, Morton GJ, Williams DL, Caldwell DW, Bastian LS, Wisse BE, Schwartz MW, Baskin DG. Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8. Am J Physiol Regul Integr Comp Physiol. 2008 Dec 24. [Epub ahead of print]
  18. Thompson R, Schreuder AB, Wisse BE, Jarman K, Givan K, Suhr L, Corl D, Pierce B, Knopp R, Goss JR.  Improving insulin ordering safely: the development of an inpatient glycemic control program.  J Hosp Med. 2009 Sep;4(7):E30-5
  19. Wisse BE, Schwartz MW.  Does hypothalamic inflammation cause obesity?  Cell Metab. 2009 Oct;10(4):241-2.
  20. Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW.  Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.  Endocrinology. 2009 Dec;150(12):5362-72. Epub 2009 Oct 9.
  21. Thaler JP, Choi SJ, Schwartz MW, Wisse BE.  Hypothalamic inflammation and energy homeostasis: resolving the paradox.  Front Neuroendocrinol. 2010 Jan;31(1):79-84. Epub 2009 Oct 12.
  22. Chiu HK, Qian K, Ogimoto K, Morton GJ, Wisse BE, Agrawal N, McDonald TO, Schwartz MW, Dichek HL.  Mice Lacking Hepatic Lipase Are Lean and Protected against Diet-Induced Obesity and Hepatic Steatosis.  Endocrinology. 2010 Jan 7. [Epub ahead of print]
  23. Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Choi SJ, Kim F, Schwartz MW, Wisse BE. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1122-30. Epub 2010 Mar 30
  24. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Oh-I S, Thaler JP, Ogimoto K, Wisse BE, Morton GJ, Schwartz MW.Am J Physiol Endocrinol Metab. 2010 Jul;299(1):E47-53. Epub 2010 Apr 6
  25. Identification of body fat mass as a major determinant of metabolic rate in mice. Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse BE, Schwartz MW.Diabetes. 2010 Jul;59(7):1657-66. Epub 2010 Apr 2
  26. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes. German JP, Wisse BE, Thaler JP, Oh-I S, Sarruf DA, Ogimoto K, Kaiyala KJ, Fischer JD, Matsen ME, Taborsky GJ Jr, Schwartz MW, Morton GJ.Diabetes. 2010 Jul;59(7):1626-34. Epub 2010 Apr 27
  27. Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice. Morton GJ, Kaiyala KJ, Fischer JD, Ogimoto K, Schwartz MW, Wisse BE. Am J Physiol Endocrinol Metab. 2010 Nov 9. [Epub ahead of print]
  28. Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. German JP, Thaler JP, Wisse BE, Oh-I S, Sarruf DA, Matsen ME, Fischer JD, Taborsky GJ Jr, Schwartz MW, Morton GJ. Endocrinology. 2011 Feb;152(2):394-404.
  29. Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice. Choi SJ, Yablonka-Reuveni Z, Kaiyala KJ, Ogimoto K, Schwartz MW, Wisse BE. Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1031-7.
  30. The impact of inpatient point-of-care blood glucose quality control testing. Corl DE, Yin TS, Hoofnagle AN, Whitney JD, Hirsch IB, Wisse BE. J Healthc Qual. 2011 May 17.
  31. Obesity is associated with hypothalamic injury in rodents and humans. Thaler JP, Yi CX,     Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. J Clin Invest. 2012 Jan 3;122(1):153-62.
  32. Lipopolysaccharide-induced lung injury is independent of serum vitamin D concentration. Klaff LS, Gill SE, Wisse BE, Mittelsteadt K, Matute-Bello G, Chen P, Altemeier WA.PLoS One. 2012;7(11):e49076
  33. Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. Kaiyala KJ, Morton GJ, Thaler JP, Meek TH, Tylee T, Ogimoto K, Wisse BE. PLoS One. 2012;7(8):e41473
  34. BDNF Action in the Brain Attenuates Diabetic Hyperglycemia via Insulin-Independent Inhibition of Hepatic Glucose Production. Meek TH, Wisse BE, Thaler JP, Guyenet SJ, Matsen ME, Fischer JD, Taborsky GJ Jr, Schwartz MW, Morton GJ.  Diabetes. 2012 Dec 28
  35. In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek TH, Ogimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ.  Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E734-46
  36. Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Diabetes. 2013 Aug;62(8):2629-34.
  37. Evaluation of point-of-care blood glucose measurements in patients with diabetic ketoacidosis or hyperglycemic hyperosmolar syndrome admitted to a critical care unit. Corl DE, Yin TS, Mills ME, Spencer TL, Greenfield L, Beauchemin E, Cochran J, Suhr LD, Thompson RE, Wisse BE. J Diabetes Sci Technol. 2013 Sep 1;7(5):1265-7
  38. Efficacy of DNET program to improve nursing confidence and expertise in caring for hospitalized patients with diabetes mellitus. Corl DE, McCliment S, Thompson RE, Suhr LD, Wisse BE. JNPD 2014 May-Jun;30(3):134-42
  39. Point-of-care blood glucose measurement errors overestimate hypoglycemia rates in critically ill patients. Nya-Ngatchou JJ, Corl D, Onstad S, Yin T, Tylee T, Suhr L, Thompson RE, Wisse BE. Diabetes Metab Res Rev. 2015 Feb;31(2):147-54
  40. Point-of-care blood glucose measurement in critically ill patients. Corl D, Greenfield L, Hoofnagle A, Baird GS, Suhr LD, Wisse BE. Critical Care Nursing 2015 (in press)
  41. Perioperative Glycemic Control During Colorectal Surgery. Thompson RE, Broussard EK, Flum DR, Wisse BE. Curr Diab Rep. 2016 Mar;16(3):32







Brent E. Wisse, MD, Curriculum Vitae, 020810