Iris Liou, MD
Disclosures: NO DISCLOSURE ON FILE
PHS 398 (Rev. 11/07), Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle):             

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.

 

NAME

Iris W. Liou

POSITION TITLE

Clinical Associate Professor of Medicine

eRA COMMONS USER NAME (credential, e.g., agency login)

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

University of Washington, Seattle, WA

BS

1996

Cell & Molecular Biology Medicine

University of Washington School of Medicine,

                 Seattle, WA

MD

2000

 

University of Washington School of Medicine,

                 Seattle, WA

 

2000-2003

Residency in Internal Medicine

University of Washington, Division of

                 Gastroenterology, Seattle, WA

 

2004-2007

Fellowship in Gastroenterology

University of Washington, Division of

                 Gastroenterology, Seattle, WA

 

2007-2008

Fellowship in Transplant

Hepatology   

University of Washington, Teaching Scholars

                 Program, Seattle, WA

 

 

2011-2012

Scholar

University of Washington, Certificate Program in

                 Patient Safety and Quality, Seattle, WA

 

2015-2016

Hepatology Scholar

PHS 398/2590 (Rev. 11/07)              Page   1                Biographical Sketch Format Page


Program Director/Principal Investigator (Last, First, Middle):             

 

 

  1. Positions and Honors

Positions and Employment

2008-2014                            Assistant Professor of Medicine, University of Washington, Seattle, WA

2014-2016                            Clinical Assistant Professor of Medicine, University of Washington, Seattle, WA

2016-present              Clinical Associate Professor of Medicine, University of Washington, Seattle, WA

2008-present              Attending Physician, University of Washington Medical Center, Seattle, WA

2008-present              Attending Physician, Harborview Medical Center, Seattle, WA

2008-present              Attending Physician, Seattle Cancer Care Alliance, Seattle, WA

2008-present              Director, Hepatology Clinic, University of Washington Medical Center, Seattle, WA

 

Other Experience and Professional Memberships

2000-present              American College of Physicians—American Society of Internal Medicine

2004-2013                            American College of Gastroenterology

2004-2015                            American Gastroenterological Association

2004-present              American Association for the Study of Liver Disease

2020-present              American Society of Transplantation

 

  1. Selected publications (in chronological order)
  1. Liou I, Kowdley KV.  Natural history of non-alcoholic steatohepatitis.  J Clin Gastroenterol 2006; 40(S1):  S11-16.
  2. Liou IW, Larson AM.  Role of transplantation in acute liver failure.  Semin Liv Dis 2008; 28(2):  201-209.
  3. Liou IW.  (2010). Miscellaneous Cystic Lesions in the Liver.  In Murray K and Larson AM (Eds), Fibrocystic Diseases of the Liver (pp 411-432).  New York:  Humana Press.
  4. Rayhill S, Schwartz J, Ham J, Carithers R, Yu L, Bhattacharya R, Liou I, Landis C, Limaye A, Rakita R, Dick A, Healey P, Halldorson J, Bakthavatsalam R, Perkins J, Reyes J.  The use of hepatitis B core antibody-positive donor livers does not appear to have a deleterious effect on graft survival in liver transplantation for hepatitis C.  Transplant Proc 2010; 42(10): 4141-4144.
  5. Diamond DL, Krasnoselsky L, Burnum KE, Monroe ME, Webb-Robertson BJ, McDermott JE, Yeh MM, Dzib JF, Susnow N, Strom S, Proll SC, Belisle SE, Purdy DE, Rasmussen AL, Walters KA, Jacobs JM, Critsenko MA, Camp DG, Bhattcharya R, Perkins JD, Carithers RL Jr, Liou IW, Larson AM, Benecke A, Waters KM, Smith RD, Katze MG. Proteome and computational analyses reveal new insights into the mechanisms of hepatitis C-virus medicated liver disease posttransplantation.  Hepatology 2012; 56(1): 28-38.
  6. Jia N, Liou I, Halldorson J, Carithers R, Perkins J, Reyes J, Yeh M, Stohr E, Rao S, Lin EH. Phase 1 adjuvant trial of sorafenib in patients with hepatocellular carcinoma after orthotopic liver transplantation. Anticancer Res 2013;33(6);2797-800.
  7. Liou IW. “Module 3: Management of Cirrhosis-Related Complications. Lessons 1-5.”  Hepatitis C Online Course.  University of Washington, September 2013.  <http://www.hepatitisc.uw.edu/go/management-cirrhosis-related-complications>.
  8. Liou IW.  Management of end-stage liver disease.  Med Clin North Am 2014; 98(1): 119-52.
  9. Dai DF, Swanson PE, Krieger EV, Liou IW, Carithers RL, Yeh MM. Congestive hepatic fibrosis score: a novel histological assessment of clinical severity.  Mod Pathol 2014 June 13 (Epub ahead of print).
  10. Fontana RJ, Ellerbe C, Durkalski VE, Rangnekar A, Reddy RK, Stravitz T, McGuire B, Davern T, Reuben A, Liou I, Fix O, Ganger DR, Chung RT, Schilsky M, Han S, Hynan LS, Sanders C, Lee WM; the US Acute Liver Failure Study Group.  Two-year outcomes in initial survivors with acute liver failure:  results from a prospective, multicentre study.  Liver Int 2014 July 12 (Epub ahead of print).
  11. Halldorson JB, Carithers RL, Bhattacharya R, Bakthavatsalam R, Liou IW, Dick AA, Reyes JD, Perkins JD. D-MELD risk capping improves post-transplant and overall mortality under Markov microsimulation.  World J Transplant 2014;4(3):206-15. [original work]
  12. Berry K, Taylor J, Liou IW, Ioannou GN. Portal vein thrombosis is not associated with increased mortality among patients with cirrhosis.  Clin Gastroenterol Hepatol 2015; 13(3):585-93. [original work]
  13. Ingraham CR, Padia SA, Johnson GE, Easterling TR, Liou IW, Kanal KM, Valji K. Transjugular intrahepatic portosystemic shunt placement during pregnancy: a case series of five patients. Cardiovasc Intervent Radiol 2015; 39(5):1205-10. [original work]
  14. Berry K, Lerrigo R, Liou IW, Ioannou GN.  Association between transjugular intrahepatic portosystemic shunt and survival in patients with cirrhosis. Clin Gastroenterol Hepatol. 2016; 14(1): 118-23. [original work]
  15. James J, Liou IW. Comprehensive care of patients with chronic liver disease. Med Clin North Am 2015;99(5):913-33. [review]
  16. Su F, Yu L, Berry K, Liou IW, Landis CS, Rayhill SC, Reyes JD, Ioannou GN. Aging of liver transplant registrants and recipients: trends and impact on waitlist outcomes, post-transplant outcomes and transplant-related survival benefit. Gastroenterology 2016; 150(2):441-453. [original work]
  17. Reuben A, Tillman H, Fontana RJ, Davern T, McGuire B, Stravitz RT, Durkalski V, Larson AM, Liou I, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh OS, Ganger D, Zaman A, Han SB, Chung RT, Smith A, Brown R, Crippin J, Harrison ME, Koch D, Munoz S, Reddy KR, Rossaro L, Satyanaryana R, Hassanein T, Hanje AJ, Olson J, Subramanian R, Karvellas C, Hameed B, Sherker AH, Robuck P, Lee WM. Outcomes in adults with acute liver failure between 1998 and 2013: an observational cohort study.  Ann Intern Med 2016; 164(11);724-32. [original work]
  18. Fix OK, Liou I, Karvellas CJ, Ganger DR, Forde KA, Subramanian RM, Boylan A, Hanje J, Stravitz RT, Lee WM; Acute Liver Failure Study Group. Development and pilot of a checklist for management of acute liver failure in the intensive care unit. PLoS One. 2016 May 13; 11(5):e0155500. [original work]
  19. Bowen SR, Chapman TR, Borgman J, Miyaoka RS, Kinahan PE, Liou IW, Sandison GA, Vesselle HJ, Nyflot MJ, Apisarnthanarax S. Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients. EJNMMI Res 2016; 6(1) :57. [original work]
  20. Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger, D, Reddy KR, Liou I, Fix O, James LP. An immunoassay to rapidly measure acetaminophen protein adducts accurately identifies patients with acute liver injury or failure. Clin Gastroenterol Hepatol. 2017;15(4):555-562. [original work]
  21. Liou IW, Nguyen MH. The cascade of care in chronic hepatitis B. Curr Hepatology Rep 2016;15:209-219. [review]
  22. Liou IW, Nguyen MH. “HBV: Current Gaps in Diagnosis and Linkage to Care” newsletter. eViralHepatitis Review. John Hopkins Medicine, March 2017. <http://eviralhepatitisreview.org/newsletters/volume-5/evh-volume-5-issue-1.html >.
  23. Liou IW, Nguyen MH. “HBV: Addressing Current Gaps in Diagnosis and Linkage to Care” podcast. eViralHepatitis Review. John Hopkins Medicine, March 2017. <http://eviralhepatitisreview.org/newsletters/volume-5/evh-volume-5-issue-2.html>.
  24. Liou IW, Kim NK. Management of Cirrhosis-Related Complications: Diagnosis and Management of Ascites. In Spach DH, Kim HN, eds. Hepatitis C Online. 2nd ed. Seattle, WA: University of Washington; 2017. <https://www.hepatitisc.uw.edu/go/management-cirrhosis-related-complications/ascites-diagnosis-management/core-concept/all>
  25. Liou IW, Kim NK. Management of Cirrhosis-Related Complications: Recognition and Management of Spontaneous Bacterial Peritonitis. In Spach DH, Kim HN, eds. Hepatitis C Online. 2nd ed. Seattle, WA: University of Washington; 2017. <https://www.hepatitisc.uw.edu/go/management-cirrhosis-related-complications/spontaneous-bacterial-peritonitis-recognition-management/core-concept/all>
  26. Liou IW, Kim NK. Management of Cirrhosis-Related Complications: Screening for Varices and Prevention of Bleeding. In Spach DH, Kim HN, eds. Hepatitis C Online. 2nd ed. Seattle, WA: University of Washington; 2017. <https://www.hepatitisc.uw.edu/go/management-cirrhosis-related-complications/varices-screening-prevention-bleeding/core-concept/all>
  27. Liou IW, Kim NK. Management of Cirrhosis-Related Complications: Diagnosis and Management of Hepatic Encephalopathy. In Spach DH, Kim HN, eds. Hepatitis C Online. 2nd ed. Seattle, WA: University of Washington; 2017. <https://www.hepatitisc.uw.edu/go/management-cirrhosis-related-complications/hepatic-encephalopathy-diagnosis-management/core-concept/all>
  28. Liou IW, Kim NK. Management of Cirrhosis-Related Complications: Screening for Varices and Prevention of Bleeding. In Spach DH, Kim HN, eds. Hepatitis C Online. 2nd ed. Seattle, WA: University of Washington; 2017. <https://www.hepatitisc.uw.edu/go/management-cirrhosis-related-complications/liver-transplantation-referral/core-concept/all>
  29. Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP. An Immunoassay to rapidly measure acetaminophen protein adducts accurately identifies patients with acute liver injury or failure. Clin Gastroenterol Hepatol 2017; 15(4):555-562. [original work]
  30. Koch DG, Speiser JL, Durkalski V, Fontana RJ, Davern T, McGuire B, Stravitz RT, Larson AM, Liou I, Fix O, Schilsky ML, McCashland T, Hay JE, Murray N, Shaikh OH, Ganger D, Zaman A, Han SB, Chung RT, Brown RS, Munoz S, Reddy KR, Rossaro L, Satyanarayana R, Hanje AJ, Olson J, Subramanian RM, Karvellas C, Hameed B, Sherker AH, Lee WM, Reuben A. The natural history of severe acute liver injury. Am J Gastroenterol 2017;112(9):1389-1396. [original work]
  31. Bajema KL, Simonson PD, Greninger AL, Coruh B, Pottinger PS, Bhattacharya R, Liou IW, Jalikis FG, Fligner CL, Rakita RM. Acute liver failure due to Echovirus 9 associated with persistent B cell depletion from rituximab. Open Form Infectious Disease, ofx174, https://doi.org/10.1093/ofid/ofx174. Published 14 August 2017. [original work]
  32. Chapman T, Bowen SR, Yeung R, Kwan SW, Park JO, Yu L, Harris WP, Johnson GE, Liou IW, Nyflot MJ, Apisarnthanarax S. Toward consensus reporting of radiation-induced liver toxicity in the treatment of primary liver malignancies: defining clinically relevant liver toxicity endpoints. Practical Radiation Oncology 2018; 8(3):157-166. [original work]
  33. Nguyen MH, Lim JK, Ozbay AB, Fraysse J, Liou I, Meyer N, Dusheiko G, Gordon SC. Advancing age and comorbidity in a United States insured population-based cohort of patients with chronic hepatitis B. Hepatology 2019; 69(3):959-973. [original work]
  34. Nguyen MH, Burak Ozbay A, Liou I, Meyer N, Gordon SC, Dusheiko G, Lim JK. Healthcare resource utilization and costs by disease severity in an insured national sample of US patients with chronic hepatitis B. J Hepatol. 2019; 70(1):24-32. [original work]
  35. Bosch DE, Koro K, Richards E, Hoch BL, Jalikis F, Koch LK, Swanson PE, Truong CD, Liou I, Yu L, Bhattacharya R, Yeh MM. Validation of a congestive hepatic fibrosis scoring system. Am J Surg Pathol. 2019; 43(6):766-772. [original work]
  36. Yu L, Liou IW, Biggins SW, Yeh M, Jalikis F, Chan LN, Burkhead J. Cooper deficiency in liver diseases: a case series and pathophysiological considerations. Hepatol Commun 2019; 3(8):1159-1165. [original work]
  37. Puri P, Lee WM, Fontana RJ, Kim NK, Durkalski V, McGuire BM, Liou I, Pezzia C, Stravitz RT; Acute Liver Failure Study Group. Alcohol consumption is associated with the severity and outcome of acute liver injury/failure. Liver Int. 2020; 40(2): 360-367. [original work]
  38. Fontana RJ, Stravitz RT, Durkalski V, Hange J, Hameed B, Koch D, Ganger D, Olson J, Liou I, McGuire BM, Clasen K, Lee WM. Prognostic value of the 13C-methacetin breath test in adults with acute liver failure and non-acetaminophen acute liver injury. Hepatology 2021 March 3. Online ahead of print. [original work]

 

  1. Research Support

5 UO1 DK058369-17 (William Lee)              9/1/15 – 8/31/20              1-3%

NIH/NIDDK              $3,425,412

A Multi-Center Trial for Acute Liver Failure (ALF)

Role: Site PI (subcontract)

Goal - in patients with severe ALI/ALF to (1) gather data concerning ALF etiology, natural history, and pathogenesis, (2) create a tissue and serum bank, and (3) study new therapies for ALF.

PHS 398/2590 (Rev. 11/07)              Page                   Continuation Format Page